Nah, it’s totally not weird to be worried about a legit anatomical problem.
As we learned from The Chainmal Chick, actual panties made from chainmail are out of the question, considering how absolutely uncomfortable (chafy and pinchy!) they would be… It’s safe to assume similarly with any other kind of underwear made of metal or other material not suitable for it… especially if it’s a g-sting/thong.
That said, it would definitely be entertaining to see, for example, a video game that decided to acknowledge most of their thong-clad heroines have functioning uteri and thus make them wear something comfortable and conservative regularly for like 1/6 of the gameplay!
You want gritty realism, AAA gamers? Then there aren’t many grittier things about everyday real life than periods! >-D
edit: Slight rewording of the initial sentence to make it more inclusive.